Building a mechanism of science and technology innovation activities in a region is required, which is to make use of the characteristics and strengths of regions and can be deployed autonomously. Therefore, universities are expected to work with such local companies as a member of the local community, and to contribute to the construction of a regional innovation system. Then, in order to clarify the achievements and issues of the industry-academia collaboration in region, the National Institute of Science and Technology Policy (NISTEP) conducted research on industry-academia collaboration to target the manufacturing industry in Kagoshima Prefecture as a case study in fiscal year 2011 (Sotohebo-Nakatake 2012). In 2012 we conducted a questionnaire survey by mail to target the 700 manufacturing companies to put headquarters, factories, and offices in Nagano prefecture, and the survey was obtained valid responses of 298 companies (42.6% response rate).Of the respondents of this survey, there is more than half (51.4%)companies had experience of cooperation with academia. Many companies initiated the industry-academia collaboration from 2005. There are 108 companies which had cooperation with Shinshu University. This is 36.2% of the total answer. In Shinshu University, research and development has been more active. In the evaluation of a result of industry-academia collaboration, improvement of technical level is high. The companies have accumulated experience of industry-academia collaboration, and they have improved the capabilities of research and development. At the same time, they have improved their capacity of the exploration of technology. Therefore, it might be said that local firms will not rely on only universities in the same region. It might be possible that there search ability of university and technical college can be developed, according to keep relationship with such technology intensive companies and to respond the pioneering needs of such companies.
