Building a mechanism of science and technology innovation activities in a region is required, which is to make use of the characteristics and strengths of regions and can be deployed autonomously. Therefore, universities are expected to work with such local companies as a member of the local community, and to contribute to the construction of a regional innovation system. Then, in order to clarify the achievements and issues of the industry academic collaboration in region, the National Institute of Science and Technology Policy (NISTEP) conducted research on industry academic collaboration to target the manufacturing industry in Kagoshima Prefecture as a case study in fiscal year 2011 (Sotohebo-Nakatake 2012). In 2012 we conducted a questionnaire survey by mail to target the 500 manufacturing companies to put headquarters, factories, and offices in Yamagata prefecture, and the survey was obtained valid responses of 211 companies (42.2% response rate).Of the respondents of this survey, there is over one third of (35.6%) companies had experience of cooperation with academia. Many companies initiated the industry academic collaboration from 2005. There are 50 companies which had cooperation with Yamagata University. This is 23.7% of the total answer. In Yamagata University, technical consultation has been more active. In the evaluation of a result of industry academic collaboration, improvement of technical level, development of new products (technology) and human resource development in the employees are high. In the industry academic collaboration in Yamagata Prefecture, technical consultation was more active than research and development. This means that universities and national technical colleges have detailed responses to the local businesses, at the same time relationships with companies and universities and national technical colleges will not have reached the stage of research and development. In order for local companies to do research and development with academia, additionally to build a relationship between universities and industry or to introduce technology seeds of universities and national technical colleges, it can be said that there is a need to grant motivation to research and development or to improve the financial strength, working together with local governments.
